1. Product Introduction:
Kinetin (/'kaɪnɪtɪn/) is a type of cytokinin, a class of plant hormone that promotes cell division. Kinetin was originally isolated by Miller and Skoog et al. as a compound from autoclaved herring sperm DNA that had cell division-promoting activity. It was given the name kinetin because of its ability to induce cell division, provided that auxin was present in the medium. Kinetin is often used in plant tissue culture for inducing formation of callus (in conjunction with auxin) and to regenerate shoot tissues from callus (with lower auxin concentration).
For a long time, it was believed that kinetin was an artifact produced from the deoxyadenosine residues in DNA, which degrade on standing for long periods or when heated during the isolation procedure. Therefore, it was thought that kinetin does not occur naturally, but, since 1996, it has been shown by several researchers that kinetin exists naturally in the DNA of cells of almost all organisms tested so far, including human and various plants. The mechanism of production of kinetin in DNA is thought to be via the production of furfural — an oxidative damage product of deoxyribose sugar in DNA — and its quenching by the adenine base's converting it into N6-furfuryladenine, kinetin.
Kinetin is also widely used in producing new plants from tissue cultures.
Kinetin is part of a group of compounds known as cytokinins, a class of growth regulators in plants. In plants, Kinetin promotes cell division and is active in the processes of cellular growth and differentiation. It also functions as an antioxidant, preventing oxidative damage caused by free radicals(Drugs.com).
Although it is proven that Kinetin can do all of these functions in plants, it has only been used in skin care and beauty products since 1994. It was made popular by its inclusion in Valeant Pharmaceutical's Kinerase, endorsed by Courtney Cox. Kinetin functions as an essential growth hormone, which can influence cell growth and differentiation by delaying and offsetting aging characteristics. By creating new cells through division, Kinetin can refresh the skin's appearance. In addition, its antioxidant properties protect the outer layers of the skin from free radicals. Kinetin has been shown to reduce wrinkles, improve skin texture, and decrease signs of mottled hyperpigmentation.A Chapel Hill, North Carolina study published in the February 2002 issue of Dermatology Times found that in a 12-week, split face study showed a 62% improvement in skin texture, clarity, discrete pigmentation, mottled pigmentation, and fine wrinkling. A study done by Revlon tested 98 subjects with mild to moderate photodamaged skin over 10 weeks and found significant improvement in texture, skin clarity, mottled pigmentation and fine wrinkling as well.
There is no available information on appropriate human doses of this plant growth hormone.
Contraindications have not yet been identified.
Information regarding safety and efficacy in pregnancy and lactation is lacking.
None well documented.
There is a very low incidence of side effects when used topically. Common side effects include erythema, peeling, burning, and stinging.
Research reveals little or no information regarding toxicology with the use of this product.
Kinetin, a cytokinin and plant hormone, is a cell division factor found in plant parts and yeast. Kinetin has also been detected in freshly extracted DNA from human cells.
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