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Introduction Of Abamectin

Dec 29, 2017


Abamectin is a mixture of avermectins containing > 80% avermectin B1a and < 20% avermectin B1b These two components, B1a and B1b have very similar biological and toxicological properties The avermectins are insecticidal or anthelmintic compounds derived from the soil bacterium Streptomyces avermitilis  Abamectin is a natural fermentation product of this bacterium . Abamectin is used to control insect and mite pests of a range of agronomic, fruit, vegetable and ornamental crops, and it is used by homeowners for control of fire ants . Doses of 50 to 200 ug/kg of ivermectin, a similar member of the avermectin family of comounds, is widely used to treat humans in the World Health Organization onchocerciasis (river blindness) program


Abamectin is a highly toxic material, however most formulated products containing abamectin are of low toxicity to mammals  Emulsifiable concentrate formulations may cause moderate eye irritation and mild skin irritation. Symptoms of poisoning observed in laboratory animals include pupil dilation, vomiting, convulsions and/or tremors, and coma Abamectin acts on insects by interfering with neural and neuromuscular transmission. It acts on a specific type of synapse located only within the brain and is protected by the blood-brain barrier. However, at very high doses, the mammalian blood-brain barrier can be penetrated, causing symptoms of CNS depression such as incoordination, tremors, lethargy, excitation and pupil dilation. Very high doses have caused death from respiratory failure

Abamectin is not readily absorbed through skin. Tests with monkeys show that less than 1% of dermally applied abamectin was absorbed into the bloodstream through the skin  Abamectin does not cause allergic skin reactions

The amount of a chemical that is lethal to one-half (50%) of experimental animals fed the material is referred to as its acute oral lethal dose fifty, or LD50. The oral LD50 for abamectin in rats is 11 mg/kg, and in mice range from 14 to > 80 mg/kg . The dermal LD50 for technical abamectin on rats and rabbits is > 330 mg/kg. The oral LD50 for the product Affirm 0.011% Fire Ant Bait in rats is > 5,000 mg/kg, and its dermal LD50 on rabbits is > 2,000 mg/kg  The oral LD50 for the 1.8% w/v Abamectin EC product in rats is 300 mg/kg, and the dermal LD50 for this product on rabbits is > 2,000 mg/kg


Abamectin is a white to yellowish crystalline powder It poses a slight fire hazard if exposed to heat or flame, and a fire and explosion hazard in the presence of strong oxidizers. It may burn but will not readily ignite. Avoid contact with strong oxidizers, excessive heat, sparks or open flame. Thermal decomposition may release toxic oxides of carbon . Workers handling abamectin should wear goggles to prevent eye contact and protective clothing to prevent prolonged skin contact Phy

CAS #: Avermectin B1a - 65195-55-3;

Avermectin B1b - 65195-56-4

Chemical name: avermectin B1a

Chemical Class/Use: avermectin acaricide/insecticide; macrocyclic lactone disaccharide isolated from the soil bacterium Streptomyces avermitilis.

Density: 1.16 at 21 degrees C

H20 solubility: practically insoluble; 7.8 ppb

Solubility in other solvents: soluble in acetone, methanol, isopropanol and toluene

Melting point: 155-157 degrees C

Vapor pressure: negligible ; 1.5 x 10 to the minus 9 torr

Koc: 4,000

sical Properties:


It is a kind of 16-membered macrolide, farm-livestock dual antibiotics with strong insecticidal, acaricidal, nematicidal activity. It is of broad-spectrum, high efficiency and safety. It has strong stomach poisoning and contact-killing effect without being able to kill the eggs. Its mechanism of action is interfering with the neuro-physiological activity, affecting the transmission of cellular membrane chloride with GABA being the target site. When the drug stimulates the target sites, it can block the transmission process of motor nerve information, resulting in the signal of central nervous systems of pest being continuously received by motor neurons, causing rapid paralysis of pests within hours, poor feeding, and slow moving or not moving. Because they do not cause rapid dehydration of insect rapid dehydration, so the lethal effect is slow. They will generally die after 24d after. It is mainly used for the prevention and treatment of various kinds of pests such as diamondback moth, cabbage caterpillar, armyworm, and flea in vegetables or fruit trees, it is particularly efficient in treating insect pests resistant to other pesticides. The amount per hectare for treating vegetable pests is 10~20g with control efficiency of over 90%; for the control of citrus rust mite: 13.5~54g per hectare with residual time being as long as 4 weeks (reduce the dose to 13.5 to 27 g upon being mixed with mineral oil by which the residue time can be extended to 16 weeks); it can be used for control of carmine spider mite, tobacco budworm, bollworm and cotton aphid with good efficacy. In addition, it can also be used to control cattle parasitic diseases, such as Damalinia bovis, Boophilus microplus, and bovine foot mite. When used for the control of parasitic diseases, the dosage is 0.2mg/kg of body weight. 
It has driving and killing effect on nematodes, insects and mites. It can be used for the treatment of nematodes disease, mite disease as well as parasitic disease of livestock and poultry. 
It has good control efficacy and delayed resistance for various kinds of pests of citrus, vegetables, cotton, apples, tobacco, soybeans and tea.
It can be used for the prevention of many kinds of pests or pest mites of vegetables, fruit and cotton.


Contact:Sally Xu