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Special Antibacterials 73231-34-2 Florfenicol Medicine for Animals

Special Antibacterials 73231-34-2 Florfenicol Medicine for Animals
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Product Details

Chemical & Physical Properties:

CAS NO: 73231-34-2

MF:C12H14Cl2FNO4S

MW:358.21

EINECS:1806241-263-5

  

Item

Specification

Color

White

Form

White or white crystalline powder

Storage temp

0-6°C

Melting Point

153°C                     

Boiling point 

618°C

 

Use:

Fluorinated derivative of thiamphenicol. Inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits.

Florfenicol is a fluorinated derivative of thiamphenicol. Florfenicol inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits. Florfenicol is used as an antibacterial.

Florfenicol is synthesised from thiamphenicol by replacing the 3-hydroxy group with fluorine, first synthesised at Schering in 1980. By replacing the hydroxy group, it was rationalised that chloramphenicol resistance via chloramphenicol acetyltransferase could be eliminated. Florfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Florfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Florfenicol has been extensively studied with over 400 literature citations.


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